Title : IGF - 1 R targeting increases the antitumor effects of DNA damaging agents in SCLC model : an opportunity to increase the efficacy of standard therapy
نویسندگان
چکیده
1. INSERM U1030, Paris XI University, Institut Gustave Roussy, Villejuif, France. 2. Department of Medicine, Institut Gustave Roussy, Villejuif, France. 3. Department of Radiotherapy, Institut Gustave Roussy, Villejuif, France. 4. Innovative Therapeutics and Early Phase Clinical Trials Unit (SITEP), Department of Medicine, Institut Gustave Roussy, Villejuif, France 5. INSERM U981, Paris XI University, Institut Gustave Roussy, Villejuif, France 6. Department of Pathology, Institut Gustave Roussy, Villejuif, France 7. Sage Bionetworks, Seattle, WA, USA.
منابع مشابه
IGF-1R targeting increases the antitumor effects of DNA-damaging agents in SCLC model: an opportunity to increase the efficacy of standard therapy.
Insulin-like growth factor receptor-1 (IGF-1R) inhibition could be a relevant therapeutic approach in small cell lung cancer (SCLC) given the importance of an IGF-1R autocrine loop and its role in DNA damage repair processes. We assessed IGF-1R and pAkt protein expression in 83 SCLC human specimens. The efficacy of R1507 (a monoclonal antibody directed against IGF-1R) alone or combined with cis...
متن کاملLarge Molecule Therapeutics IGF-1R Targeting Increases the Antitumor Effects of DNA- DamagingAgents in SCLCModel: AnOpportunity to Increase the Efficacy of Standard Therapy
Insulin-like growth factor receptor-1 (IGF-1R) inhibition could be a relevant therapeutic approach in small cell lung cancer (SCLC) given the importance of an IGF-1R autocrine loop and its role in DNA damage repair processes. We assessed IGF-1R and pAkt protein expression in 83 SCLC human specimens. The efficacy of R1507 (amonoclonal antibody directed against IGF-1R) alone or combinedwith cispl...
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